| 胃粘膜肠上皮化生SC3A的免疫组织化学研究 |
| |
| 引用本文： | 吴继锋,杨光霖,董聿明,王道斌,刘民培.胃粘膜肠上皮化生SC3A的免疫组织化学研究[J].中国组织化学与细胞化学杂志,1999(3). |
| |
| 作者姓名： | 吴继锋 杨光霖 董聿明 王道斌 刘民培 |
| |
| 作者单位： | 安徽医科大学病理解剖学教研室!合肥230032(吴继锋，杨光霖，董聿明，王道斌)，沈阳军区总医院医学实验科!沈阳110015(刘民培) |
| |
| 摘 要： | 应用免疫组织化学ＡＢＣ方法等检测６２ 例胃良、恶性病变伴肠化组织中单克隆抗体ＳＣ３Ａ的表达及意义。结果： 癌旁肠化硫酸粘液阳性率明显较良性病变伴肠化高； 硫酸粘液阳性组肠化ＳＣ３Ａ阳性率明显高于硫酸粘液阴性组； 而且ＳＣ３Ａ 阳性率在酸性粘液阳性组胃癌明显高于酸性粘液阴性组； 硫酸粘液阳性组胃癌明显高于硫酸粘液阴性组。提示结肠型肠化可能与肠型胃癌的发生有一定关系
|
| 关 键 词： | 肠化 免疫组织化学 单克隆抗体 人 |
IMMUNOHISTOCHEMICAL STUDY OF MONOCLONAL ANTIBODY SC3A IN INTESTINAL METAPLASIA OF GASTRIC MUCOSA |
| |
| Wu Jifeng,Yang Guanglin,Dong Yuming,et al.IMMUNOHISTOCHEMICAL STUDY OF MONOCLONAL ANTIBODY SC3A IN INTESTINAL METAPLASIA OF GASTRIC MUCOSA[J].Chinese Journal of Histochemistry and Cytochemistry,1999(3). |
| |
| Authors: | Wu Jifeng Yang Guanglin Dong Yuming |
| |
| Abstract: | To study the significance of monoclonal antibody SC3A expression in intestinal metaplasia of gastric mucosa, immunohistochemical staining (ABC method) for SC3A and mucin histochemical staining were performed in 62 cases of intestinal metaplasia from gastric benign and malignant lesions. The results showed that the positive rate of sulphomucin was significantly higher in intestinal metaplasia with cancer than that of intestinal metaplasia with benign lesion. The positve rate of SC3A in intestinal metaplasia with sulphomucin was singificantly higher than that without sulphomucin. The positive rate of SC3A in cancers secreting acid mucin or sulphomucin was significantly higher than that in cancers without acid mucin or sulphomucin. It suggests that the colonic type of intestinal metaplasia may be related to the intestinal type of gastric carcinoma. |
| |
| Keywords: | Intestinal metaplasia Immunohistochemistry Monoclonal antibody Human |
| 本文献已被 CNKI 等数据库收录！ |
