| 甲型流感病毒HA基因的简单重复序列分布分析 |
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| 引用本文： | 彭军,谭钟扬,蔡立军,易丽萍,赵相艳.甲型流感病毒HA基因的简单重复序列分布分析[J].生物信息学,2011,9(1):54-59. |
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| 作者姓名： | 彭军 谭钟扬 蔡立军 易丽萍 赵相艳 |
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| 作者单位： | 湖南大学,湖南,长沙,410082 |
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| 基金项目： | 湖南省自然科学基金(07JJ5085); 湖南省科技计划项目(2008CKI3070) |
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| 摘 要： | 以GenBank公开的甲型流感病毒亚型的血凝素(hemagglutinin,HA)核苷酸序列为材料,从简单重复序列(simple se-quence repeat,SSR)分布的分析角度出发,分析了来自于亚洲、非洲、北美洲、南美洲、欧洲、大洋洲的49个地区的76株甲流病毒的HA片段。分析表明:所分析序列的SSRs的分布都很相似,其中单碱基重复的相对丰度值和相对密度值均高于其它五种碱基重复的相对丰度值和相对密度值;甲流病毒HA片段的SSRs与HIV-116]基因中的SSRs相比,前者的相对丰度值和相对密度值高于后者。这些结果表明甲流病毒基因中的SSRs可能与甲流病毒的快速变异相关。
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| 关 键 词： | 甲型流感 简单重复序列 血凝素 |
Distributional analysis of SSRs in hemagglutinin sequences of influenza A viruses |
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| PENG Jun,TAN Zhong-yang,CAI Li-jun,YI li-ping,ZHAO Xiang-yan.Distributional analysis of SSRs in hemagglutinin sequences of influenza A viruses[J].China Journal of Bioinformation,2011,9(1):54-59. |
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| Authors: | PENG Jun TAN Zhong-yang CAI Li-jun YI li-ping ZHAO Xiang-yan |
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| Institution: | PENG Jun,TAN Zhong-yang,CAI Li-jun,YI li-ping,ZHAO Xiang-yan (Hunan University,Changsha 410082,China) |
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| Abstract: | We undertook a survey of the simple sequence repeats （SSRs） in the HA sequences which consisted in the influenza A virus genomes and retrieved from GenBank.Distribution of SSRs was examined in 76 HA sequences which came from 49 different countries or districts over Asia、Africa、North America、South America and Oceania.Our results indicated that,the distribution of SSRs in the sequences of HA was highly similar,but mononucleotide repeats was higher than the other five types of nucleotide repeats on relative abundance and relative density.Compared with the HIV-116],both the relative abundance and relative density of SSRs in HA sequences of influenza A viruses were higher.The results suggested that SSRs in HA sequences seemed to be associated with the rapid variation of the influenza A viruses. |
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| Keywords: | influenza virus A simple sequence repeat hemagglutinin |
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