The effect of juglone on cholinergic mechanisms in rat brain synaptosomes |
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| Authors: | Jack R. Cooper Katalin Piros |
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| Affiliation: | (1) Department of Pharmacology, Yale University School of Medicine, 06510 New Haven, Connecticut |
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| Abstract: | Juglone 5-hydroxy-1,4-napthoquinone exerts three activities on cortical synaptosomal preparations. It inhibits the release of acetylcholine and is an even more potent inhibitor of high-affinity choline transport into synaptosomes. In addition, as has already been shown by others using brain homogenates, juglone inhibits choline acetyltransferase. |
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