Effects of angiotensin II on isolated toad (Bufo arenarum) aortic rings |
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| Authors: | M Peral de Bruno P Lebenshon de Chialvo A Coviello |
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| Institution: | Departamento de Fisiología, INSIBIO, San Miguel de Tucumán, Argentina. |
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| Abstract: | 1. The vascular response to Asn1-Val5 angiotensin II (A II) in aortic rings from Bufo arenarum toad was studied. 2. Tachyphylaxis in response to A II could be abolished after incubation with norepinephrine (NE). 3. Phentolamine treatment partially inhibited the pressor effects to A II. 4. Sar1-Ile8 A II and Sar1-Ala8 A II significantly attenuated the vascular effects of A II and did not affect the NE response. 5. We conclude that the pressor response to A II has a direct contractile effect and a catecholamine dependent component in aortic rings of Bufo arenarum toad. |
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