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Factor XIII-mediated cross-linking of NH2-terminal peptide of alpha 2-plasmin inhibitor to fibrin |
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| Authors: | A Ichinose T Tamaki N Aoki |
| Institution: | Department of Biochemistry, University of Bath, Bath BA2 7AY, England |
| Abstract: | The NH2-terminal 12-residue peptide of alpha 2-plasmin inhibitor, Asn-Gln-Glu-Gln-Val-Ser-Pro-Leu-Thr-Gly-Leu-Lys-NH2 . AcOH, was found to be a good substrate for plasma transglutaminase (activated blood coagulation factor XIII) and rapidly incorporated into fibrin by the enzyme. A high concentration of the peptide inhibited the enzyme-mediated cross-linking of alpha 2-plasmin inhibitor to fibrin probably by competing with the inhibitor for the same site of fibrin alpha-chain. |
| Keywords: | Fibrin Factor XIII Plasma transglutaminase Cross-linking Glutamine substrate XIIIa activated coagulation factor XIII N-peptide To whom correspondence should be addressed |
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