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Piroxicam enhances phagocytosis of Escherichia coli by human polymorphonuclear neutrophils |
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| Authors: | E Lingaas T Midtvedt |
| Affiliation: | Kaptein W. Wilhelmsen og Frues Bakteriologiske Institutt University of Oslo, Rikshospitalet, Oslo, Norway. |
| Abstract: | Human polymorphonuclear neutrophils were exposed to piroxicam, 1.5 uM, 15 uM and 150 uM during phagocytosis of radiolabelled Escherichia coli in vitro. Preincubation of the cells for 30 minutes before phagocytosis stimulated the uptake of E. coli at all concentrations. The elimination of substances of bacterial origin from the neutrophis in the postingestion phase was, however, not influenced by piroxicam. |
| Keywords: | PMN polymorphonuclear leukocytes or neutrophils KRG Krebs-Ringer phosphate buffer, pH 7.4, enriched with 10 mM glucose PMA phorbol myristate acetate CTC chlortetracycline FMLP N-formyl-methionyl-leucyl-phenylalanine |
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