Studies on DNA Damage and Repair in the Mammalian Brain |
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| Authors: | A. P. Walker H. S. Bachelard |
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| Affiliation: | Division of Biochemistry, U.M.D.S., St. Thomas's Hospital, London, England. |
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| Abstract: | Methods for studying breaks in DNA strands and their repair, originally developed for prokaryotes and cultured cell lines, have been applied to preparations from rat brain. The relative sensitivities of these methods, which include alkaline sucrose density gradient sedimentation, nucleoid sedimentation, and ADP-ribosyltransferase assay, are compared. |
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| Keywords: | DNA damage DNA repair ADP-ribosyltransferase |
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