Changes in adrenergic receptors during the development of heart failure |
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Authors: | Naranjan S Dhalla Ian M C Dixon Shingo Suzuki Masanori Kaneko Akira Kobayashi Robert E Beamish |
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Institution: | (1) Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Avenue, R2H 2A6 Winnipeg, Manitoba, Canada;(2) Department of Physiology, Faculty of Medicine, University of Manitoba, R2H 2A6 Winnipeg, Manitoba, Canada |
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Abstract: | Moderate and severe stages of congestive heart failure due to the loss of myocardium upon coronary occlusion in rats was associated with an increase in alpha-adrenergic receptors and a decrease in beta-adrenergic receptors in the viable left ventricle. However, at early stages of heart failure the number of beta-adrenergic receptors was decreased without any changes in the number of alpha-adrenergic receptors. The affinities of these receptors to alpha receptor antagonist (3H-prazosin) and beta receptor antagonist (3H-dihydroalprenolol) were not altered in the failing hearts. On the other hand, the pattern of changes in both alpha- and beta-adrenergic receptors in heart membranes treated with oxygen free radical generating system was different from that seen in the failing hearts. In particular, the affinities for these receptors were decreased whereas the number of beta-receptors was increased and the number of alpha-receptors was decreased or unchanged. These results indicate that alterations in the adrenergic receptors in heart failure are not due to the formation of oxygen free radicals. |
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Keywords: | beta-adrenoceptors alpha-adrenoceptors heart failure free radicals heart membranes |
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