Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities |
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| Authors: | Jew Sang-sup Park Boon-saeng Lim Doo-yeon Kim Myoung Goo Chung In Kwon Kim Joo Hee Hong Chung Il Kim Joon-Kyum Park Hong-Jun Lee Jun-Hee Park Hyeung-geun |
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| Institution: | Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, South Korea. ssjew@plaza.snu.ac.kr |
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| Abstract: | Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity. |
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