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Design and in vivo activity of A3 adenosine receptor agonist prodrugs |
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| Authors: | Suresh R. Rama Jain Shanu Chen Zhoumou Tosh Dilip K. Ma Yanling Podszun Maren C. Rotman Yaron Salvemini Daniela Jacobson Kenneth A. |
| Affiliation: | 1.Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8A, Rm. B1A-19, 9000 Rockville Pike, Bethesda, MD, 20892-0810, USA ;2.Department of Pharmacology and Physiology, Saint Louis University, St. Louis, MO, USA ;3.Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University, St. Louis, MO, USA ;4.Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA ; |
| Abstract: | Purinergic Signalling - Prodrugs (MRS7422, MRS7476) of highly selective A3 adenosine receptor (AR) agonists Cl-IB-MECA and MRS5698, respectively, were synthesized by succinylation of the 2′... |
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