Body fat distribution has no effect on serum visfatin levels in healthy female subjects |
| |
| Authors: | Canan Ersoy Ganime Sadikoglu Hasan Orhan Metin Guclu Emre Sarandol Meral Demirci Akgun Alis Ozcakir Sazi Imamoglu |
| |
| Affiliation: | 1. Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK;3. Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;6. Department of Biochemistry, Golestan University, Gorgan, Iran;7. Health Sciences Research Center, Department of Health and Management, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran;8. Health Sciences Research Center, Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran;9. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK;1. Postgraduate Program in Biochemistry, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil;2. Postgraduate Program in Pharmaceutical Sciences, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil;3. Course of Pharmacy, Federal University of Pampa, Uruguaiana, Rio Grande do Sul, Brazil |
| |
| Abstract: | Obesity is the presence of either abnormal absolute amount or relative proportion of body fat. Contrary to gluteal obesity, visceral obesity is associated with different metabolic alterations including insulin resistance (IR). A relatively new adipocytokine visfatin is shown to be expressed predominantly in visceral fat and exhibit insulin-mimicking effects in rodents. It is still unclear whether serum visfatin levels are associated with increased total or visceral fat mass in humans. The aim of our study was to investigate the relation between visfatin and obesity parameters namely body mass index (BMI) and waist circumference (WaC) and IR in healthy female subjects. Eighty one female subjects ?20 years of age, having no diagnosis of glucose intolerance or diabetes, hypertension and dyslipidemia were chosen. The patients were divided into four groups according to their BMI and WaC values. Serum visfatin and HOMA-IR levels did not differ among groups. No correlation was detected between serum visfatin levels and obesity and metabolic parameters. In conclusion, we demonstrated that body fat distribution did not affect serum visfatin levels in healthy female subjects. Further studies are needed to clarify the exact factors influencing and determining serum visfatin levels and its clinical reflections. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
