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Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer |
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| Authors: | Drill Matthew Jones Nigel C. Hunn Martin O’Brien Terence J. Monif Mastura |
| Affiliation: | 1.Department of Neuroscience, Faculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, VIC, Australia ;2.Department of Physiology, Melbourne University, Parkville, VIC, Australia ;3.Department of Neurology, Alfred Health, Melbourne, VIC, Australia ;4.Department of Neurosurgery, Alfred Hospital, Melbourne, VIC, Australia ;5.Department of Neurology, Melbourne Health, Parkville, VIC, Australia ; |
| Abstract: | Purinergic Signalling - The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular ATP associated with a wide variety of cellular functions. It is most commonly expressed on... |
| Keywords: | Purinergic receptors P2X7 receptor Antagonists Inflammation Cancer |
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