Metalloantimalarials: synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone |
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| Authors: | Gokhale Nikhil H Shirisha K Padhye Subhash B Croft Simon L Kendrick Howard D Mckee Vickie |
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| Institution: | Department of Chemistry, University of Pune, Ganeshkhind Road, Pune-411007, India. |
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| Abstract: | The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target. |
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