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Proton beam therapy for cancer in the era of precision medicine
Authors:Man Hu  Liyang Jiang  Xiangli Cui  Jianguang Zhang  Jinming Yu
Affiliation:1.Shandong Cancer Hospital Affiliated to Shandong University,Jinan,China;2.Shandong Academy of Medical Sciences,Jinan,China;3.Departments of Radiation Oncology and Shandong Province Key Laboratory of Radiation Oncology,Shandong Cancer Hospital and Institute,Jinan,China;4.Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei,China;5.Departments of Radiation Oncology,Zibo Wanjie Cancer Hospital,Zibo,China
Abstract:Precision radiotherapy, which accurately delivers the dose on a tumor and confers little or no irradiation to the surrounding normal tissue and organs, results in maximum tumor control and decreases the toxicity to the utmost extent. Proton beam therapy (PBT) provides superior dose distributions and has a dosimetric advantage over photon beam therapy. Initially, the clinical practice and study of proton beam therapy focused on ocular tumor, skull base, paraspinal tumors (chondrosarcoma and chordoma), and unresectable sarcomas, which responded poorly when treated with photon radiotherapy. Then, it is widely regarded as an ideal mode for reirradiation and pediatrics due to reducing unwanted side effects by lessening the dose to normal tissue. During the past decade, the application of PBT has been rapidly increasing worldwide and gradually expanding for the treatment of various malignancies. However, to date, the role of PBT in clinical settings is still controversial, and there are considerable challenges in its application. We systematically review the latest advances of PBT and the challenges for patient treatment in the era of precision medicine.
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