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Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives |
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| Authors: | Shi Xue-Liang Ge Jian-Feng Liu Bao-Qiang Kaiser Marcel Wittlin Sergio Brun Reto Ihara Masataka |
| Affiliation: | Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, 199 Ren'Ai Road, Suzhou 215123, China. |
| Abstract: | A series of 5-phenyliminobenzo[a]phenoxazine derivatives were synthesized. The in vitro antiprotozoal activities were evaluated against Plasmodium falciparum K1, Trypanosoma cruzi, Leishmania donovani and Trypanosoma brucei rhodesiense. N,N-Diethyl-5-((4-methoxyphenyl)imino)-5H-benzo[a]phenoxazin-9-amine shows IC(50)=0.040 μmol L(-1) with a selective index of 1425 against Plasmodium falciparum K1. |
| Keywords: | Antiprotozoal Benzo[a]phenoxazine In vitro Plasmodium falciparum Nile blue |
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