Evaluation of Antifungal Activity of Medicinal Plant Extracts Against Oral <Emphasis Type="Italic">Candida albicans</Emphasis> and Proteinases |
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| Authors: | José Francisco Höfling Rita Cássia Mardegan Paula Cristina Anibal Vivian Fernandes Furletti Mary Ann Foglio |
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| Institution: | 1.Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba,FOP/UNICAMP Universidade Estadual de Campinas,Piracicaba,Brazil;2.Departamento de Diagnóstico Oral pela Faculdade de Odontologia de Piracicaba,FOP/UNICAMP,Piracicaba,Brazil;3.Coordenadora da Divis?o de Fitoquímica do,CPQBA/UNICAMP,Campinas,Brazil |
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| Abstract: | Proteinases produced by Candida albicans are one kind of virulence factor expressed that contribute to adherence and invasion of host tissue. Proteinase inhibitor
of human immunodeficiency virus in experimental candidiasis suggested reduction in fungal infection, and medicinal plants
could be a source of alternative agent to prevent diseases. In this study, we investigated the production of proteinases by
C. albicans from clinical isolates and the action of plant extracts against strains of C. albicans and its synthesized proteinases, comparing with antifungal fluconazole and amphotericin B and proteinase inhibitors pepstatin
A, amprenavir, and ritonavir. The results reported here showed that these extracts have a certain kind of action and that
the search for new antifungal agents could be found at the plants. |
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