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Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance |
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| Authors: | Joyce JBC van Beers Reinout Raijmakers Lou-Ella Alexander Judith Stammen-Vogelzangs Angelique MC Lokate Albert JR Heck Richard BM Schasfoort Ger JM Pruijn |
| Affiliation: | (1) Department of Biomolecular Chemistry, Nijmegen Center for Molecular Life Sciences, Institute for Molecules and Materials, Radboud University, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands;(2) Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Padualaan 8, NL-3584 CH Utrecht, The Netherlands;(3) Medical Cell Biophysics Group, MIRA institute, University of Twente, PO Box 217, NL-7500 AE Enschede, The Netherlands;(4) IBIS Technologies B.V, Pantheon 5, NL-7521 PR Enschede, The Netherlands |
| Abstract: | IntroductionRheumatoid arthritis (RA) frequently involves the loss of tolerance to citrullinated antigens, which may play a role in pathogenicity. Citrullinated fibrinogen is commonly found in inflamed synovial tissue and is a frequent target of autoantibodies in RA patients. To obtain insight into the B-cell response to citrullinated fibrinogen in RA, its autoepitopes were systematically mapped using a new methodology. |
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