Angiotensin II receptor antagonists (AT1-blockers,ARBs, sartans): similarities and differences

A survey is presented of the registered non-peptidergic angiotensin II receptor antagonists (AT₁ blockers, ARBs, sartans) and their general properties and similarities. Accordingly, their receptor profile, pharmacokinetic and therapeutic applications are discussed. In addition, attention is paid to the individual characteristics of the AT₁ blockers now available. A few components of this category offer additional potentially beneficial properties, owing to their pharmacological or metabolic characteristics. Such additional properties are critically discussed for eprosartan, losartan, telmisartan and valsartan.