X-ray diffraction studies of the RNA tetramer GpGpCpUp |
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| Authors: | Hiroshi Mizuno Ken-Ichi Tomita Eiko Nakagawa Eiko Ohtsuka Morio Ikehara |
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| Institution: | Laboratory of Physical Chemistry Faculty of Pharmaceutical Sciences Osaka University, Suita, Osaka 565, Japan;Laboratory of Organic Chemistry Faculty of Pharmaceutical Sciences Osaka University, Suita, Osaka 565, Japan |
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| Abstract: | The synthetic RNA tetramer GpGpCpUp has been studied by X-ray diffraction of single crystals and fibres. A preliminary crystallographic analysis of single crystals implies that two GpGpCpUp strands form a short antiparallel double helix with G · U base-pairs at the ends of it. As diffraction intensities of single crystals fall into decay, the diffraction pattern gradually changes into a fibre pattern similar to that of A-RNA or of the A form of DNA. |
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