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Analysis of long-lived substates of the conductivity of single ion channels
Authors:V N Kazachenko  V I Geletiuk
Abstract:
Using the patch-voltage-clamp method kinetic parameters of single ionic channels were studied. It was found that the channels have long-lasting conductance substates along with the short-living ones. The conductance of a long-lasting substate fluctuates near an average sublevel in the boundaries of a restrict number (k) of elementary conductance steps. There is a direct relationship: the greater k, the longer is average duration (tau k) of the substate. For a given k the falling phase of tau k value distribution is approximately one-exponential. The substates of k-th order result in the multi-exponentiality of the ion current kinetics.
Keywords:
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