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Conserved and species-specific alternative splicing in mammalian genomes |
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| Authors: | Ramil N Nurtdinov Alexey D Neverov Alexander V Favorov Andrey A Mironov Mikhail S Gelfand |
| Affiliation: | (1) Faculty of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Vorbyevy Gory 1-73, Moscow, 119992, Russia;(2) State Research Institute for Genetics and Selection of Industrial Microorganisms, GosNIIGenetika, 1st Dorozhny proezd 1, Moscow, 117545, Russia;(3) Division of Oncology Biostatistics and Bioinformatics, The Sidney Kimmel Cancer Center at Johns Hopkins, 550 North Broadway, Suite 1103, Baltimore, MD 21205, USA;(4) Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoi Karenty pereulok 19, Moscow, 127994, Russia |
| Abstract: | BackgroundAlternative splicing has been shown to be one of the major evolutionary mechanisms for protein diversification and proteome expansion, since a considerable fraction of alternative splicing events appears to be species- or lineage-specific. However, most studies were restricted to the analysis of cassette exons in pairs of genomes and did not analyze functionality of the alternative variants. |
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