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Biological evaluation of phenolic constituents from the trunk of Berberis koreana |
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| Authors: | Kim Ki Hyun Moon Eunjung Choi Sang Un Kim Sun Yeou Lee Kang Ro |
| Institution: | a Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon 440-746, Republic of Korea b East-West Medical Science Integrated Research Center, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 449-701, Republic of Korea c Korea Research Institute of Chemical Technology, Teajeon 305-600, Republic of Korea |
| Abstract: | A bioassay-guided fractionation and chemical investigation of the trunk of Berberis koreana resulted in the isolation and identification of a new sesquilignan, named berbikonol (1), along with fourteen known lignan derivatives (2-15) and a new phenolic compound, named berfussinol (16), together with five known ones (17-21). The structures of these new compounds were elucidated on the basis of 1D and 2D NMR spectroscopic data analysis as well as circular dichroism (CD) spectroscopy studies. Compounds 1-5, 7-8, 11, and 14 showed significant cytotoxicity against the XF498 cell line with IC50 values of 7.14-19.32 μM. In addition, compounds 3-8 and 15 strongly reduced nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 cells, a microglial cell line. |
| Keywords: | Berberis koreana Berberidaceae Phenolic Cytotoxicity Neuroinflammation |
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