Pharmacokinetic modelling of [2-13C]uracil metabolism in normal and DPD-deficient dogs |
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| Authors: | Inada M Hirao Y Koga T Itose M Kunizaki J Shimizu T Sato H |
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| Affiliation: | Research Section, Diagnostics Division, Otsuka Pharmaceutical Co Ltd, Japan. inadam@otsuka.jp |
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| Abstract: | A physiologically based pharmacokinetic (PBPK) model to simulate the plasma concentration and 13CO2 exhalation after [2-13C]uracil administration to DPD-suppressed dogs was developed. Simulation using this PBPK model should be useful in clinical situations where DPD-deficient patients at risk are to be detected with [2-13C]uracil as an in vivo probe. |
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