Autoradiographic localizatio of [125I]-C-ANP compared to [125I]-ANP in rat tissue |
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| Authors: | F Heidemann W Steinke U Pleiss G Theiss K-P Voges S Kazda R Gerzer J-P Stasch |
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| Institution: | (1) Institute of Pharmacology, Bayer A.G. Research Center, Postfach 101709, W-5600 Wuppertal, Federal Republic of Germany;(2) Institute of Pharmacokinetics, Bayer A.G. Research Center, Postfach 101709, W-5600 Wuppertal, Federal Republic of Germany;(3) Institute of Biochemistry, Bayer A.G. Research Center, Postfach 101709, W-5600 Wuppertal, Federal Republic of Germany;(4) Institute of Chemistry, Bayer A.G. Research Center, Postfach 101709, W-5600 Wuppertal, Federal Republic of Germany;(5) Laboratory for Clinical Pharmacology, Medizinische Klinik Innenstadt der Ludwig-Maximilians-Universität, W-8000 München, Federal Republic of Germany |
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| Abstract: | Summary Whole-body autoradiography demonstrated the different distribution of 125I]-C-ANP and 125I]-ANP to rat tissues. Highest enrichment of radioactivity of both labelled peptides was found in the kidney. In some organs we found remarkable differences between 125I]-ANP and 125I]-C-ANP. In the kidney cortex, especially in the glomeruli, as well as in the endocardium, the zona glomerulosa and the medulla of the adrenal gland, where high levels of radioactivity after 125I]-ANP administration were detected, no or just few radioactivity was found after administration of 125I]-C-ANP. On the other hand in the kidney papilla and the outer subcortical medulla, characteristic blackening was found after 125I]-C-ANP administration. Those differences might be important for the understanding of pharmacological actions of ANP analogues.This work is part of the doctoral thesis of Frank Heidemann to be presented at the Ludwig-Maximilians-Universität München, FRG |
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