Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists |
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| Authors: | Link J T Sorensen B Liu G Pei Z Reilly E B Leitza S Okasinski G |
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| Affiliation: | Metabolic Disease Research, Abbott Laboratories, Abbott Park, IL 60064, USA. james.link@abbott.com |
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| Abstract: | 
Diarylsulfide cyclopropylamides were synthesized and evaluated as LFA-1/ICAM-1 interaction antagonists. A substituent pattern was identified which maximized potency and minimized protein binding as exemplified by antagonist 30 (IC50 = 5 nM). |
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