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Sequence patches on MAPK surfaces define protein-protein interactions |
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| Authors: | Gary L Johnson Shawn M Gomez |
| Affiliation: | (1) Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA;(2) Joint Department of Biomedical Engineering, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7365, USA |
| Abstract: | Recent studies on the modularity of mitogen-activated protein kinases show how redesigning 'surface patches' on a protein can change the topology of a signaling network. |
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