Effects of anterior pituitary hormones on hepatic corticosterone metabolism in rats |
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| Authors: | H D Colby J H Gaskin J I Kitay |
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| Institution: | 1. Division of Endocrinology and Metabolism Departments of Internal Medicine and Physiology University of Virginia School of Medicine Charlottesville, Virginia 22901 USA;2. Department of Physiology and Biophysics West Virginia University School of Medicine Morgantown, West Virginia 26506 USA |
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| Abstract: | Experiments were conducted to determine the effects of anterior pituitary hormones on hepatic corticosterone metabolism in rats. Hypophysectomy lowered A-ring reduction but did not affect sidechain metabolism. Administration of prolactin, FSH, LH or FSH + LH to hypophysectomized rats affected neither process. Similarly, ACTH or growth hormone, when given alone, did not affect corticosterone metabolism. However, combined treatment with ACTH and growth hormone significantly reduced the rate of ring A metabolism, suggesting that hormonal interactions may be important in the control of hepatic steroid metabolism. |
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