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Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues |
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| Authors: | Matthijs van der Knaap Eefje Engels Henk J Busscher Jos M Otero Antonio L Llamas-Saiz Mark J van Raaij Roos H Mars-Groenendijk Daan Noort Gijsbert A van der Marel Herman S Overkleeft Mark Overhand |
| Institution: | Matthijs van der Knaap, Eefje Engels, Henk J. Busscher, José M. Otero, Antonio L. Llamas-Saiz, Mark J. van Raaij, Roos H. Mars-Groenendijk, Daan Noort, Gijsbert A. van der Marel, Herman S. Overkleeft,Mark Overhand, |
| Abstract: | The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified d-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reported. |
| Keywords: | Anti-microbial peptides Gramicidin S derivatives Biological profile |
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