The state of the antioxidant system during therapy of patients with multiple sclerosis |
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Authors: | L P Smirnova N V Krotenko E V Grishko N M Krotenko V M Alifirova S A Ivanova |
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Institution: | (1) Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan;(2) Department of Anatomy, Keio University School of Medicine, Tokyo 160-8582, Japan;(3) Center for Integrated Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan |
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Abstract: | Activity of erythrocyte glutathione peroxidase (GPx), glutathione reductase (GR), glutathione transferase (GT), glucose-6-phosphate
dehydrogenase (G6PDH), catalase and superoxide dismutase (SOD), the level of erythrocyte malonic dialdehyde (MDA) and also
total antioxidant activity of blood serum were studied in patients with different types of multiple sclerosis (MS). Investigation
of peripherical blood was carried out on the first day of admission to the hospital and after the standard therapy with copaxone.
During the whole period of observation all MS patients had a high level of MDA and activity of erythrocyte GP compared with
a control group. Other erythrocyte antioxidant enzymes and total antioxidant activity of blood serum exhibited weak positive
dynamics in patients with relapsing-remitting multiple sclerosis (RRMS). The pathological decrease of antioxidant system activity
in patients with secondary progressive multiple sclerosis (SPMS) was more pronounced and remained unchanged after the treatment.
This is consistent with a more severe clinical course of this disease. |
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