Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity |
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| Authors: | Buhm Han,Dorothé e Diogo,Steve Eyre,Henrik Kallberg,Alexandra Zhernakova,John Bowes,Leonid Padyukov,Yukinori Okada,Miguel A. Gonzá lez-Gay,Solbritt Rantapä ä -Dahlqvist,Javier Martin,Tom W.J. Huizinga,Robert M. Plenge,Jane Worthington,Peter K. Gregersen,Lars Klareskog,Paul I.W. de Bakker,Soumya Raychaudhuri |
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| Affiliation: | 1 Division of Genetics, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA;2 Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;3 Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA 02115, USA;4 Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02115, USA;5 Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK;6 NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK;7 Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital Solna, 171 76 Stockholm, Sweden;8 Department of Rheumatology, Leiden University Medical Centre, 2300 RC Leiden, the Netherlands;9 Department of Genetics, University Medical Center Groningen and University of Groningen, 9700 RB Groningen, the Netherlands;10 Rheumatology Division, Hospital Universitario Marqués de Valdecilla, Instituto de Formación e Investigación Marqués de Valdecilla, 39008 Santander, Spain;11 Department of Public Health and Clinical Medicine and Department of Rheumatology, Umeå University, 901 85 Umeå, Sweden;12 Instituto de Parasitologia y Biomedicina Lopez-Neyra, Consejo Superior de Investigaciones Cientificas, 18100 Armilla, Granada, Spain;13 Merck Research Laboratories, Merck & Co. Inc., Boston, MA 02115, USA;14 The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, NY 11030, USA;15 Departments of Epidemiology and Medical Genetics, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands |
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