Methylenedioxy- and methoxyflavones from Melicope coodeana syn. Euodia simplex |
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Authors: | Simonsen Henrik T Larsen Michael D Nielsen Merete W Adsersen Anne Olsen Carl Erik Strasberg Dominique Smitt Ulla W Jaroszewski Jerzy W |
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Institution: | a Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark b Department of Chemistry, Royal Veterinary and Agricultural University, Thorvaldsensvej 40, DK-1871, Frederiksberg, Denmark c Laboratoire de Biologie et Physiologie Végétales, Faculté des Sciences et Technologies, Université de La Réunion, F-97715 St.-Denis, Messag Cedex 9, France |
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Abstract: | Three new natural products, 3,8-dimethoxy-5,7-dihydroxy-3′,4′-methylenedioxyflavone, 3,6,8-trimethoxy-5,7-dihydroxy-3′,4′-methylenedioxyflavone and 3,6,8,3′,4′-pentamethoxy-5,7-dihydroxyflavone were isolated from Melicope coodeana syn. Euodia simplex (Rutaceae) along with 3,6,3′-trimethoxy-5,7,4′-trihydroxyflavone and 3,3′-dimethoxy-5,7,4′-trihydroxyflavone. The structural assignments are based on 1H and 13C NMR data, including discussion of the chemical shifts of C-2 in 3,5-dihydroxy- and 3-methoxy-5-hydroxyflavones. The presence of highly methoxylated and methylenedioxyflavones is characteristic of the genus Melicope, and the present findings support the recent transfer of Euodia simplex to Melicope. |
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Keywords: | Euodia simplex Melicope coodeana Rutaceae Methylenedioxyflavones Methoxyflavones 13C NMR Chemotaxonomy Réunion Island |
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