Complex genome evolution in Anopheles coluzzii associated with increased insecticide usage in Mali |
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Authors: | Bradley J Main Yoosook Lee Travis C Collier Laura C Norris Katherine Brisco Abdrahamane Fofana Anthony J Cornel Gregory C Lanzaro |
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Institution: | 1. Vector Genetics Laboratory, UC Davis, Davis, CA, USA;2. Department of Pathology, Microbiology and Immunology, UC Davis, Davis, CA, USA;3. Department of Entomology and Nematology, University of California, Davis, CA, USA;4. Malaria Research and Training Center, University of Bamako, Bamako, Mali |
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Abstract: | In certain cases, a species may have access to important genetic variation present in a related species via adaptive introgression. These novel alleles may interact with their new genetic background, resulting in unexpected phenotypes. In this study, we describe a selective sweep on standing variation on the X chromosome in the mosquito Anopheles coluzzii, a principal malaria vector in West Africa. This event may have been influenced by the recent adaptive introgression of the insecticide resistance gene known as kdr from the sister species Anopheles gambiae. Individuals carrying both kdr and a nearly fixed X‐linked haplotype, encompassing at least four genes including the P450 gene CYP9K1 and the cuticular protein CPR125, have rapidly increased in relative frequency. In parallel, a reproductively isolated insecticide‐susceptible A. gambiae population (Bamako form) has been driven to local extinction, likely due to strong selection from increased insecticide‐treated bed net usage. |
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Keywords: | adaptive introgression
Anopheles
epistasis hybridization insecticide resistance
kdr
malaria vector P450 |
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