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The Shuttling Scaffold Model for Prevention of Yeast Pheromone Pathway Misactivation |
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| Authors: | Aditya P. Singh Erik Andries Jeremy S. Edwards Stanly Steinberg |
| Affiliation: | 1. 8133/5 Stadium Road, Opposite YPS, Patiala, 147001, India 2. Department of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, 87131, USA 3. Department of Mathematics, Central New Mexico Community College, Albuquerque, NM, 87131, USA 4. Molecular Genetics and Microbiology, Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA 5. Chemical and Nuclear Engineering, University of New Mexico, Albuquerque, NM, 87131, USA |
| Abstract: | The molecular scaffold in the yeast pheromone pathway, Ste5, shuttles continuously between the nucleus and the cytoplasm. Ste5 undergoes oligomerization reaction in the nucleus. Upon pheromone stimulation, the Ste5 dimer is rapidly exported out of the nucleus and recruited to the plasma membrane for pathway activation. This clever device on part of the yeast cell is thought to prevent pathway misactivation at high enough levels of Ste5 in the absence of pheromone. We have built a spatiotemporal model of signaling in this pathway to describe its regulation. Our present work underscores the importance of spatial modeling of cell signaling networks to understand their control and functioning. |
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