| 2019冠状病毒病的发病机制研究进展 |
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| 引用本文： | 徐进川,范小勇.2019冠状病毒病的发病机制研究进展[J].微生物与感染,2020,15(6):421-428. |
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| 作者姓名： | 徐进川 范小勇 |
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| 作者单位： | 复旦大学附属公共卫生临床中心，上海 201058 |
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| 基金项目： | “十三五”传染病重大专项(2018ZX10731301, 2018ZX10302301)；国家自然科学基金(31771004)；上海市科委项目(19XD1403100, 17ZR1423900) |
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| 摘 要： | 由严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2，SARS-CoV-2)引起的病毒性肺炎已经扩散到全球200多个国家和地区，导致了数十万人死亡。2019冠状病毒病(coronavirus disease 19，COVID-19)的流行病学、致病机制和临床治疗方法成为各国政府以及科研界亟待研究解决的重大问题。本文对SARS-CoV-2的病原学特征及COVID-19的发病机制、病理学研究进展进行综述，重点评述病毒受体人血管紧张素转换酶Ⅱ (human angiotensin-converting enzyme 2，ACE2)与病毒致病机制的相关性，为后续研究与防治提供参考。
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| 关 键 词： | 严重急性呼吸综合征冠状病毒2 2019冠状病毒病 致病机制 病理学 |
Progress on pathogenesis of coronavirus disease 2019 |
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| XU Jinchuan,FAN Xiaoyong.Progress on pathogenesis of coronavirus disease 2019[J].Journal of Microbes and Infection,2020,15(6):421-428. |
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| Authors: | XU Jinchuan FAN Xiaoyong |
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| Institution: | Shanghai Public Health Clinical Center, Fudan University, Shanghai 201058, China |
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| Abstract: | A viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already spread to more than 200 countries and regions around the world, resulting in hundreds of thousands of deaths. A better understanding of epidemiology, pathogenesis, and clinical treatment of coronavirus disease 19 (COVID-19) is an essential step for efficient disease control. In this review, the advances in the pathogenesis and pathology of COVID-19 are reviewed, with emphasis on the correlation between virus receptor ACE2 and pathogenesis. |
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| Keywords: | Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 19 Pathogenesis Pathology |
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