| 致瘤性DNA病毒的整合机制及致瘤效应 |
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| 引用本文： | 喻正源,宋亚莉,龚朝建,曾朝阳,卢建红,李小玲,熊炜,李桂源.致瘤性DNA病毒的整合机制及致瘤效应[J].生物化学与生物物理进展,2014,41(4):324-331. |
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| 作者姓名： | 喻正源 宋亚莉 龚朝建 曾朝阳 卢建红 李小玲 熊炜 李桂源 |
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| 作者单位： | 中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013,中南大学湘雅医学院附属肿瘤医院，湖南省肿瘤医院，长沙 410013；中南大学肿瘤研究所，卫生部癌变原理重点实验室及教育部癌变与侵袭原理重点实验室，长沙 410078；中南大学湘雅三医院疾病基因组研究中心，湖南省非可控性炎症与肿瘤重点实验室，长沙 410013 |
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| 基金项目： | 国家高新技术研究发展计划(863)(2012AA02A206), 国家“111”计划(111-2-12), 国家自然科学基金(81171930, 81171931, 81172189, 81272254, 81272298, 181372907, 91229122)和湖南省自然科学基金(14JJ1010)资助项目 |
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| 摘 要： | 恶性肿瘤是一种严重危害人类生命和健康的疾病,而致瘤性DNA病毒是多种恶性肿瘤的主要致病因子.致瘤性DNA病毒的整合可以使宿主细胞正常组织逐步向炎症组织转变,并可导致癌变.病毒整合可引起宿主细胞基因组不稳定和重排,产生新的融合基因,并导致宿主基因表达异常,也是病毒本身得以复制,逃避宿主免疫识别并长期维系自我生存的机制之一.本文综述了目前对致瘤性DNA病毒整合规律以及致瘤性DNA病毒整合致瘤效应的研究和进展,并展望致瘤性DNA病毒整合的研究方向以及在肿瘤发生、发展、诊断和治疗上的应用前景.
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| 关 键 词： | 致瘤性DNA病毒 整合 肿瘤 基因组 新一代测序技术 |
| 收稿时间： | 2012/11/13 0:00:00 |
| 修稿时间： | 9/8/2013 12:00:00 AM |
The Mechanism and Tumorigenesis of Oncogenic DNA Virus Integration |
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| YU Zheng-Yuan,SONG Ya-Li,GONG Zhao-Jian,ZENG Zhao-Yang,LU Jian-Hong,LI Xiao-Ling,XIONG Wei and LI Gui-Yuan.The Mechanism and Tumorigenesis of Oncogenic DNA Virus Integration[J].Progress In Biochemistry and Biophysics,2014,41(4):324-331. |
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| Authors: | YU Zheng-Yuan SONG Ya-Li GONG Zhao-Jian ZENG Zhao-Yang LU Jian-Hong LI Xiao-Ling XIONG Wei and LI Gui-Yuan |
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| Institution: | Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine,Central South University, Changsha 410013, China;Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China,Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine,Central South University, Changsha 410013, China;Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center,the Third Xiangya Hospital, Central South University, Changsha 410013, China,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China,Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine,Central South University, Changsha 410013, China;Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center,the Third Xiangya Hospital, Central South University, Changsha 410013, China,Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine,Central South University, Changsha 410013, China;Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center,the Third Xiangya Hospital, Central South University, Changsha 410013, China and Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine,Central South University, Changsha 410013, China;Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute, Central South University, Changsha 410078, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center,the Third Xiangya Hospital, Central South University, Changsha 410013, China |
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| Abstract: | |
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| Keywords: | oncogenic DNA virus tumor integration genome the next generation sequence technology |
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