内皮素的研究进展

<正> 内皮素(Endothelin ET)是Yanagisawa等于1988年从猪主动脉内皮细胞培养液中分离纯化的一种由21个氨基酸残基构成,具有强烈收缩血管作用的小分子生物活性肽。ET是目前已知体内作用最强、作用时间最久的缩血管物质,在全身血压和局部血流灌注调控中可能具有重要的作用,实验证明,儿茶酚胺、神经肽Y(NPY)、凝血

Advances in the Research of Endothelin

Endothelin is a biological active peptide which is produced by the vascular endotheliocyte, it has vehement effects on the vasoconstriction and consists of twenty one amino acids. Some biotoxin, suchas Sarafotoxin, their construction are similar to it. Mammals can compound three Endothelin. Today, their position of producing, the process of synthesis and the order of arrange of amino acids have been known. Except effect on the vascular smooth muscle. endothelin also extensive act on others organs tissue. The variation of the circulation contents have major meaning in many cardiovascular diseases.