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Physical fine mapping of genes underlying X-linked deafness and non fra(X)-X-linked mental retardation at Xq21 |
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| Authors: | I. Bach D. Robinson N. Thomas H. -H. Ropers F. P. M. Cremers |
| Affiliation: | (1) Department of Human Genetics, University Hospital Nijmegen, P.O. Box 9101, NL-6500 Nijmegen, HB, The Netherlands;(2) Wessex Regional Genetics Laboratory, General Hospital Salisbury, SP2 7SX Wiltshire, UK;(3) Institute of Medical Genetics, University Hospital of Wales, CF4 4XN Heath Park, Cardiff, UK |
| Abstract: | Summary Linkage studies and cytogenetically visible deletions associated with nonspecific X-linked mental retardation (XLMR) and a specific form of deafness (DFN3) have indicated that the genes responsible for these disorders are located at Xq21. Using DNA probes from this region, we have studied several overlapping deletions spanning different parts of Xq21. This has enabled us to assign the DFN3 gene and a gene for nonspecific XLMR to an interval that encompasses the locus DXS232 and that is flanked by DXS26 and DXS121. |
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