Role of cell-mediated immunity in the resistance to experimental sporotrichosis in mice |
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| Authors: | Akio Shiraishi Kazuhide Nakagaki DVM PhD MS Tadashi Arai |
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| Institution: | (1) Servicio de Microbiología, Hospital General Virgen de las Nieves, Granada;(2) Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain;(3) Laboratorio de Microbiologia, Hospital La Inmaculada, Avda. Guillermo Reina s/n, 04600 Huercal-Overa, Almeria, Spain |
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| Abstract: | The in vitro activity of several new imidazoles, cloconazole, sulconazole, butoconazole, isoconazole and fenticonazole, were compared with those of amphothericin B, flucytosine, and three azoles: econazole, miconazole and ketoconazole against isolates of pathogenic Candida. A total of 186 clinical isolates of 10 species of the genus Candida and two culture collection strains were tested by an agar-dilution technique. Isoconazole was the most active azole, followed by butoconazole and sulconazole. Differences between some of the species in their susceptibility to the antifungal agents were noted. Sulconazole and cloconazole had the highest activity in vitro against 106 isolates of C. albicans. Butoconazole and isoconazole were also very active against isolates of C. albicans, and were the most active azole compounds against 80 isolates of Candida spp. |
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| Keywords: | Butoconazole cloconazole fenticonazole imidazoles isoconazole sulconazole in vitro susceptibility Candida |
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