大黄蛰虫胶囊联合维生素C钠治疗黄褐斑的疗效及对血清和血液流变学的影响

目的:研究大黄蛰虫胶囊联合维生素C钠治疗黄褐斑的临床疗效及对血清和血液流变学的影响。方法:选取2012年8月到2013年8月我院收治的黄褐斑患者140例,按照随机数字表法平均分成研究组和对照组,每组70例,研究组给予大黄蛰虫胶囊联合维生素C钠治疗,对照组给予大黄蛰虫胶囊治疗,两组均治疗1个月。3个月后比较两组临床疗效,并检测两组患者的血清睾酮(T)、雌二醇(E2)、孕酮(P)、过氧化脂质分解产物丙二醛(MDA)、超氧化物歧化酶(SOD)以及血液流变学水平的变化。结果:研究组总有效率85.7%(60/70)显著高于对照组的57.1%(40/70),两组比较差异具有统计学意义(P0.05);与治疗前和对照组相比,治疗后研究组SOD、E2显著升高,MDA、T显著降低,差异均具有统计学意义(P0.05);两组P水平均无明显变化;治疗后研究组血液流变学各指标较治疗前和对照组显著下降,差异均有统计学意义(均P0.05)。结论:大黄蛰虫胶囊联合维生素C钠治疗黄褐斑具有较好的临床疗效,可以调节患者的性激素水平,改善患者的血流变学。

Clinical Effect of Dahuang Zhechong Capsule Combined with Vitamin C Sodium in the Treatment of Chloasma and its Effect on Serumand Blood Rheology

Objective:To study the clinical effect of Dahuang Zhechong capsule combined with vitamin C sodium in the treatment of chloasma and its effect on serum and blood rheology.Methods:140 cases of chloasma patients from August 2012 to August 2013 in our hospital were divided into study group and control group according to the random number table method, with 70 cases in each group. The study group were treated by Dahuang Zhechong capsule combined with vitamin C, and the control group was given Dahuang Zhechong capsule treatment, all patients were treated for 1 months. The clinical efficacy was compared and the serum testosterone(T), estradiol(E2), progesterone(P) malondialdehyde(MDA), superoxide dismutase (SOD) and the changes of hemorrheologic level of two groups were detected after 3 months of treatment.Results:The total effective rate of the study group was 85.7% (60/70), significantly higher than 57.1%(40/70) of the control group , the difference was statistically significant(P<0.05); Compared with before treatment and with the control group, SOD, E2 levels of the study group significantly increased, MDA, T level significantly reduced after treatment,the difference was statistically significant (P<0.05); P levels of the two groups presented no obvious change; After treatment, hemorheological indexes of the study group significantly decreased compared with before treatment and with those of the control group, the difference was statistically significant (all P<0.05);Conclusion:Dahuang Zhechong capsule combined with vitamin Csodiumpresents good curative effect in the treatment of chloasma, can regulate the level of sex hormone and improve hemorheological.