| 紫杉醇对NK-92MI细胞杀伤功能及凋亡的影响 |
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| 引用本文： | 李建华,傅炜昕,侯佳宜,秦博,贾秀坤,范世光,梁再赋. 紫杉醇对NK-92MI细胞杀伤功能及凋亡的影响[J]. 微生物学杂志, 2008, 28(2): 30-35 |
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| 作者姓名： | 李建华 傅炜昕 侯佳宜 秦博 贾秀坤 范世光 梁再赋 |
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| 作者单位： | 1. 中国医科大学,基础医学院病理学教研室及附属第一医院,辽宁,沈阳,110001
2. 中国医科大学,实验技术中心,辽宁,沈阳,110001 |
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| 基金项目： | 教育部留学回国人员科研启动基金 |
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| 摘 要： | 探讨紫杉醇对人自然杀伤细胞系NK-92MI细胞株杀伤活性及凋亡的影响。用不同浓度的紫杉醇处理NK.92MI细胞后,测定NK-92MI细胞的增殖率和对靶细胞的杀伤作用;同时检测NK·92MI细胞凋亡率及凋亡相关基因Bcl-2、Ba】【的表达。结果表明,紫杉醇可以抑制NK-92MI细胞增殖并且降低其杀伤活性,机制可能是通过诱导NK.92MI细胞的凋亡,而后者与Bcll2/Ba】【基因表达增高有关。
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| 关 键 词： | 紫杉醇 NK-92MI细胞 凋亡 Bcl-2 Bax |
| 文章编号： | 1005-7021(2008)02-0030-06 |
| 修稿时间： | 2008-01-08 |
Effect of Paclitaxel on Killing Function and Apoptosis of NK-92MI Cells |
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| LI Jian-hu,FU Wei-xin,HOU Jia-yi,QIN Bo,JIA Xiu-kun,FAN Shi-guang,LIANH Zai-fu. Effect of Paclitaxel on Killing Function and Apoptosis of NK-92MI Cells[J]. Journal of Microbiology, 2008, 28(2): 30-35 |
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| Authors: | LI Jian-hu FU Wei-xin HOU Jia-yi QIN Bo JIA Xiu-kun FAN Shi-guang LIANH Zai-fu |
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| Abstract: | NK-92MI cells were treated with different concentration of paclitaxel respectively to study the effect of pa- clitaxel on killing activity and apoptosis of NK-92MI cells.The proliferation rate and cytotoxicity of the cells were de- tected after the treatment.The cell apoptosis rate and the expression of apoptosis-related genes Bcl-2 and Bax were ob- served.The results showed that paclitaxel could inhibit the cell proliferation and reduce its cytotoxicity that may be caused by paclitaxel-induced apoptosis of the cells.The molecular mechanism of paclitaxel-induced apoptosis of NK- 92MI cells may be associated with the increasing expression of Bax/Bcl-2. |
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| Keywords: | paclitaxel NK-92MI cell Bcl-2 Bax |
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