Pattern of afferents to the lateral septum in the guinea pig |
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Authors: | J F Staiger F Nürnberger |
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Institution: | (1) Department of Anatomy and Cytobiology, Justus Liebig University, Giessen, Germany;(2) Department of Anatomy and Cytobiology (Anatomy I, Professor A. Oksche), Aulweg 123, D-6300 Giessen, Germany |
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Abstract: | Summary The septal region represents an important telencephalic center integrating neuronal activity of cortical areas with autonomous processes. To support the functional analysis of this brain area in the guinea pig, the afferent connections to the lateral septal nucleus were investigated by the use of iontophoretically applied horseradish peroxidase (HRP). Retrogradely labeled perikarya were located in telencephalic, diencephalic, mesencephalic and metencephalic sites. The subnuclei of the lateral septum (pars dorsalis, intermedia, ventralis, posterior) receive afferents from the (i) medial septal nucleus, diagonal band of Broca (pars horizontalis and pars ventralis), and the principal nucleus of the stria terminalis, the hippocampus, and amygdala (nucleus medialis); (ii) the medial habenular nucleus, and the para- (peri-) ventricular, parataenial and reuniens nuclei of the thalamus; the anterior, lateral and posterior hypothalamic areas in particular, the medial and lateral preoptic, suprachiasmatic, periventricular, paraventricular, arcuate, premammillary, and supramammillary nuclei; (iii) the periaquaeductal grey, ventral tegmental area, nucleus interfascicularis, nucleus reticularis linearis, central linear nucleus, interpeduncular nucleus; (iv) dorsal and medial raphe complex, and locus coeruleus. Each subnucleus of the lateral septum displays an individual, differing pattern of afferents from the above-described regions. Based on a double-labeling method, the vasopressinergic and serotonergic afferents to the lateral septum were found to originate in the nucleus paraventricularis hypothalami and the raphe nuclei, respectively.Abbreviations
ARC
arcuate nucleus
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BNST
bed nucleus of the stria terminalis
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CL
central linear nucleus
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DBBh
diagonal band of Broca (pars horizontalis)
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DBBv
diagonal band of Broca (pars ventralis)
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DR
dorsal raphe nucleus
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HC
hippocampus
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IF
interfascicular nucleus
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IP
interpeduncular nucleus
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LC
locus coeruleus
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LDT
laterodorsal tegmental nucleus
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LHA
lateral hypothalamic area
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LPO
lateral preoptic area
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LSN
lateral septal nucleus
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MA
medial amygdaloid nucleus
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MH
medial habenular nucleus
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MPO
medial preoptic region
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MR
medial raphe nucleus
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MSN
medial septal nucleus
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PAG
periaquaeductal grey
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PEN
periventricular nucleus
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PHA
posterior hypothalamic area
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PMd
premammillary region (pars dorsalis)
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PMv
premammillary region (pars ventralis)
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PT
parataenial nucleus
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PVN
paraventricular hypothalamic nucleus
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PVT
paraventricular thalamic nucleus
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RE
nucl. reuniens
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RL
nucl. reticularis linearis
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SCN
suprachiasmatic nucleus
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SMl
supramammillary region (pars lateralis)
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SMm
supramammillary region (pars medialis)
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SUB
subiculum
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TS
triangular septal nucleus
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VTA
ventral tegmental area
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ac
anterior commissure
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bc
brachium conjunctivum
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bp
brachium pontis
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cc
corpus callosum
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fr
fasciculus retroflexus
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fx
fornix
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ml
medial lemniscus
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mlf
fasciculus longitudinalis medialis
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mp
mammillary peduncle
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mt
mammillary tract
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oc
optic chiasm
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on
optic nerve
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pc
posterior commissure
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pt
pyramidal tract
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sm
stria medullaris
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st
stria terminalis
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vhc
ventral hippocampal commissure
Supported by the Deutsche Forschungsgemeinschaft (Nu 36/2-1) |
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Keywords: | Lateral septal nucleus Afferent projections Peptidergic neurons Aminergic neurons Horseradish peroxidase (HRP) method Guinea pig |
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