Unilateral Dampening of Bmp Activity by Nodal Generates Cardiac Left-Right Asymmetry期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Unilateral Dampening of Bmp Activity by Nodal Generates Cardiac Left-Right Asymmetry

Authors:	Justus Veerkamp Franziska Rudolph Zoltan Cseresnyes Florian Priller Cécile Otten Marc Renz Liliana Schaefer Salim Abdelilah-Seyfried

Affiliation:	1. Cardiovascular Department, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany;2. Confocal and 2-Photon Microscopy Core Facility, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany;3. German Rheumatism Research Center (DRFZ), a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany;4. Institute for General Pharmacology and Toxicology, Goethe University, Theodor-Stern Kai 7, 60590 Frankfurt/Main, Germany

Abstract:	Download : Download high-res image (213KB) Download : Download full-size image Highlights? Cardiac laterality involves Nodal modulating an antimotogenic Bmp activity ? The Nodal target Hyaluronan synthase 2 unilaterally dampens Bmp signaling activity ? Nonmuscle myosin II is positively regulated by Bmp within cardiac tissue ? High levels of nonmuscle myosin II activity reduce cardiac cell motility

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