1. The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research and Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA;2. Department of Systems Medicine and Bioengineering, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA;3. Department of Surgery, The Methodist Hospital, Houston, TX 77030, USA
Abstract:
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Highlights? Obesity enhances MHCII expression in primary human and mouse adipocytes ? Adipocytes activate CD4+ ARTs via MHCII and leptin to induce adipose inflammation ? Macrophage changes in adipose follow adipocyte and T cell interactions during HFD ? Adaptive immune mechanisms are essential to obesity-induced adipose inflammation
