1. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3H7, Canada;2. Department of Physiology, College of Medicine and Aging-Associated Vascular Disease Research Center, Yeungnam University, Daegu 705-717, Korea;3. National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea;4. Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada;5. Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON M5S 1A8, Canada;6. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada;7. Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada
Abstract:
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Highlights? Two-way modulations of adipose VEGF were generated with aP2-Cre transgene ? Adipose VEGF KO reduces vasculature, increases hypoxia and inflammation in fat ? Adipose VEGF KO accelerates the development of metabolic disease in high-fat diet ? Induced adipose VEGF has opposite effect on fat and restores metabolic homeostasis
