Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development |
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Authors: | Bruno M Fonseca Georgina Correia-da-Silva Anthony H Taylor Justin C Konje Stephen C Bell Natércia A Teixeira |
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Institution: | 1. Servi?o de Bioquímica, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal 2. Instituto de Biologia Molecular e Celular da Universidade do Porto (IBMC), Porto, Portugal 3. Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
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Abstract: | Background Although there is growing evidence that endocannabinoids play a critical role in early pregnancy, there are no studies describing
the possible targets for this system after implantation. The endometrial stroma, which undergoes extensive proliferation and
differentiation giving rise to the decidua and the trophoblast cells that invade after the initial stages of implantation,
are potential targets. Since high anandamide (AEA) levels, the main endocannabinoid, are detrimental to implantation and in
order to gain insight into the role of the endocannabinoid system in the development of the fetoplacental unit, the spatio-temporal
pattern of expression of the anandamide-binding receptors, CB1, CB2 and the vanilloid receptor (TRPV1), were investigated
by quantitative RT-PCR, western blot and immunohistochemistry. |
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Keywords: | |
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