Common antigenic determinants in the glycoproteins of plants,molluscs and insects |
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Authors: | Loic Faye Maarten J Chrispeels |
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Institution: | (1) Centre National de la Recherche Scientifique-UA 203, Université de Rouen, Faculté des Sciences, F76130 Mont Saint Aignan, France;(2) Department of Biology, University of California, San Diego, 92093-0016 La Jolla, California, USA |
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Abstract: | An antiserum raised against -fructosidase isolated from the cell walls of suspension-cultured carrot cells cross-reacts with many plant proteins and hemocyanin ofHelix pomatia. The shared epitope appears to be a small complex glycan with a (1–2)-linked xylose residue attached to the -linked mannose residue of the core of an asparagine-linked oligosaccharide. There is strong cross-reactivity with the proteins of many seed plants, molluscs and insects, and no cross-reactivity with the proteins of fungi, algae, mosses, ferns, or any of the vertebrates tested. Xylose-containing glycans appear to increase the immunogenicity of the proteins to which they are attached, and we suggest that they may be responsible for some allergic responses of people that are repeatedly exposed to plant or insect proteins. |
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Keywords: | plant glycoproteins xylose-containing glycans antibodies (against glycans) insect glycoproteins mollusc glycoproteins |
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