A coding SNP of <Emphasis Type="Italic">LHX4</Emphasis> gene is associated with body weight and body length in bovine |
| |
Authors: | G Ren H Chen L Z Zhang X Y Lan T B Wei M J Li Y J Jing C Z Lei J Q Wang |
| |
Institution: | (1) College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi, 712100, China;(2) Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou, Jiangsu, 221116, China;(3) Research Center of Cattle Engineering Technology in Henan, Zhengzhou, Henan, 450003, China |
| |
Abstract: | Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency. In this study, the polymorphism of LHX4-HaeIII locus was revealed in 822 individuals from four Chinese cattle breeds. The PCR–RFLP analysis showed that there were three
genotypes: GG, GA, AA. The frequencies of genotype GG ranged from 0.6620 to 0.9789 in analyzed populations. The genotypic
frequencies of LHX4 locus in the four populations all agreed with Hardy–Weinberg equilibrium (P > 0.05). Distributions of genotypic frequencies of different breeds (QC, NY, JX, CH) at this locus were found to be significantly
different based on a χ
2 test (P < 0.001). The genetic diversity analysis revealed the JX cattle possessed intermediate genetic diversity, and the other three
Chinese cattle breeds belonged to poor genetic diversity. Correlation analysis with growth traits in the NY breed indicated
that: the animals with genotype GA had greater body weight than those with genotype GG (P < 0.05); the animals with GA genotype owned significantly longer body length than the ones with GG genotype (P < 0.05) at 18 and 24 months. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|