The MEMPACK alpha-helical transmembrane protein structure prediction server |
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Authors: | Nugent Timothy Ward Sean Jones David T |
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Institution: | Department of Computer Science, University College London, London, UK. t.nugent@cs.ucl.ac.uk |
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Abstract: | MOTIVATION: The experimental difficulties of alpha-helical transmembrane protein structure determination make this class of protein an important target for sequence-based structure prediction tools. The MEMPACK prediction server allows users to submit a transmembrane protein sequence and returns transmembrane topology, lipid exposure, residue contacts, helix-helix interactions and helical packing arrangement predictions in both plain text and graphical formats using a number of novel machine learning-based algorithms. AVAILABILITY: The server can be accessed as a new component of the PSIPRED portal by at http://bioinf.cs.ucl.ac.uk/psipred/. |
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