华石斛化学成分研究

为了解华石斛(Dendrobium sinense)的化学成分,采用多种柱色谱技术从其全草乙醇提取液中分离纯化了10个化合物,经波谱分析分别鉴定为:鼓槌石斛素(1)、2′,4′-二羟基查尔酮(2)、2,5,7-三羟基-4-甲氧基-9,10-二氢菲(3)、4,7-二羟基-2,3-二甲氧基-9,10-二氢菲(4)、2,5-二羟基-3,4-二甲氧基-9,10-二氢菲(5)、2,7-二羟基-3,4,6-三甲氧基-9,10-二氢菲(6)、(E)松柏醛(7)、反式对羟基肉桂酸酯(8)、对羟基苯丙酸甲酯(9)和十二元内环酯(10)。所有化合物均为首次从华石斛中分离得到,其中化合物2、6、7和10对乙酰胆碱酯酶具有一定的抑制活性。

Chemical Constituents from Dendrobium sinense

In order to understand the chemical constituents of Dendrobium sinense, ten compounds were isolated from whole herb by column chromatography. On the basis of spectral data, their structures were identified as chrysotoxine (1), 2'',4''-dihydroxy chalcone (2), 2,5,7-trihydroxy-4-methoxy-9,10-dihydrophenanthrene (3), 4,7-dihydroxy-2,3-dimethoxy-9,10-dihydrophenanthrene (4), 2,5-dihydroxy-3,4-dimethoxy-9,10-dihydrophenanthrene (5), 2,7-dihydroxy-3,4,6-trimethoxy-9,10-dihydrophenanthrene (6), (E)-coniferyl aldehye (7), trans-p-hydroxylethyl cinnamate (8), p-hydroxyphenylpropionic methyl ester (9) and lasiodiplodin (10). All the compounds were obtained from this plant for the first time. Compounds 2, 6, 7 and 10 had a certain inhibitory activity on acetyl-cholinesterase.