Apoptotic sensitivity of murine IAP-deficient cells |
| |
| Authors: | Rumble Julie M Bertrand Mathieu J M Csomos Rebecca A Wright Casey W Albert Lori Mak Tak W Barker Philip A Duckett Colin S |
| |
| Institution: | Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA. |
| |
| Abstract: | Although numerous studies have implicated the IAPs (inhibitor of apoptosis proteins) in the control of apoptotic cell death, analyses of murine Iap-targeted cells have not revealed significant differences in their susceptibility to apoptosis. In the present study, we show that, under defined conditions, murine cells lacking XIAP (X-linked inhibitor of apoptosis) and c-IAP (cellular IAP) 2, but not c-IAP1, exhibit heightened apoptotic sensitivity to both intrinsic and extrinsic apoptotic stimuli. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
